Kyle MacLea
Dr. Kyle MacLea is an Associate Professor of Biological Sciences and Biotechnology at UNH Manchester where he teaches courses in the areas of molecular biology and microbiology. His research interests include prions and amyloids in yeast and human disease, microbial genetics and genomics, particularly of bacteria and bacteriophages. In the past he has also studied the biology of molting and limb regeneration in decapod crustaceans (such as crabs, lobsters, and crayfish). A member of the Council on Undergraduate Research and the Genome Consortium for Active Teaching, Dr. MacLea is keenly interested in involving undergraduate biology students in authentic scientific research experiences, inside and outside of the classroom.
Profile
Dr. Kyle MacLea is an Assistant Professor of Biology at UNH Manchester where he teaches courses in the areas of molecular biology and microbiology. His research interests include prions and amyloids in yeast and human disease, microbial genetics, and the biology of molting and limb regeneration in decapod crustaceans (such as crabs, lobsters, and crayfish). A member of the Council on Undergraduate Research and the Genome Consortium for Active Teaching, Dr. MacLea is keenly interested in involving undergraduate biology students in authentic scientific research experiences, inside and outside of the classroom.
Courses Taught
- BIOL 413: Principles of Biology I Lab
- BIOL/BSCI 413/599: Principles of Biology I Lab
- BIOL/BSCI 414/599: Principles of Biology II Lab
- BIOT 418: Phage Bioinformatics Lab
- BIOT 515: MYS Second Yr Seminar
- BIOT 753/754/853: Cell Culture
- BIOT 753/853: Cell Culture
- BIOT 799/896: Biotechnology Seminar
- BIOT 853: Cell Culture Lab
- BIOT 888: Graduate Independent Study
- BIOT 891/892/893/895: Applied Research
- BIOT 891/892/895: Applied Research
- BIOT 892: Graduate Internship
- BIOT 893: Directed Graduate Research
- BIOT/BSCI 837/737: Microbial Genomics Lab
- BIOT/BSCI 897/620: Top/Survey of Int'l Biotech
- BIOT/BSCI 897/797: Top/RNA Biology & Innovations
- BMS 503: General Microbiology
- BMS 602: Pathogenic Microbiology
- BSCI 418/599: Phage Bioinformatics Lab
- BSCI 599: Topics/Bacter Adapt & Evol
- BSCI 620: Global Science Exploration
- BSCI 695: Exploring Biology Teaching
- BSCI 701: Senior Seminar I
- BSCI 792: Research
- BSCI 793: Internship
- KIN 684: Emer Med Care:Emer Med Techn
- KIN 685: Emer Med Care: EMT Lab
Research Interests
- Evolution
- Genetic Engineering
- Genetics
- Genomics
- Microbiology
- Prion Disease
- Regenerative Medicine
- Science Education
- Synthetic Biology
Selected Publications
Siddiqui, F. A., Trudel, S., Goen, A. E., Fatima, S. A., & MacLea, K. S. (2022). Draft Genome Sequence of Xanthobacter aminoxidans ATCC BAA-299(T). MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 11(8). doi:10.1128/mra.00548-22
Fedorov, E. A., Omeragic, M., Shalygina, K. F., Farwell, A. C., & MacLea, K. S. (2022). High-Quality Draft Genome Sequence of Kibdelosporangium philippinense, Generated by Hybrid Assembly of Short and Long Sequencing Reads. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 11(4). doi:10.1128/mra.00020-22
Maurais, E. G., Iannazzi, L. C., & MacLea, K. S. (2022). Genome Sequence of Litorilinea aerophila, an Icelandic Intertidal Hot Springs Bacterium. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 11(2). doi:10.1128/MRA.01206-21
Jr, S. M., & MacLea, K. S. (2021). Genome Sequence of the Thermophilic Soil Bacterium Ureibacillus terrenus ATCC BAA-384(T). MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 10(48). doi:10.1128/MRA.01054-21
Ulker, M., Siddiqui, F. A., Gerton, T. J., Anastasi, R. E., Conroy, D. J., Edwards, E. G., . . . MacLea, K. S. (2021). Closed Genome Sequence of Yavru, a Novel Arthrobacter globiformis Phage. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 10(45). doi:10.1128/MRA.00986-21
Abuhagr, A. M., Blindert, J. L., Nimitkul, S., Zander, I. A., LaBere, S. M., Chang, S. A., . . . Mykles, D. L. (2014). Molt regulation in green and red color morphs of the crab Carcinus maenas: gene expression of molt-inhibiting hormone signaling components. JOURNAL OF EXPERIMENTAL BIOLOGY, 217(5), 796-808. doi:10.1242/jeb.093385
Abuhagr, A. M., MacLea, K. S., Chang, E. S., & Mykles, D. L. (2014). Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: Cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 168, 25-39. doi:10.1016/j.cbpa.2013.11.008
Kim, H. J., Kim, N. C., Wang, Y. -D., Scarborough, E. A., Moore, J., Diaz, Z., . . . Taylor, J. P. (2013). Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. NATURE, 495(7442), 467-+. doi:10.1038/nature11922
Krieser, R. J., MacLea, K. S., Longnecker, D. S., Fields, J. L., Fiering, S., & Eastman, A. (2002). Deoxyribonuclease II alpha is required during the phagocytic phase of apoptosis and its loss causes perinatal lethality. CELL DEATH AND DIFFERENTIATION, 9(9), 956-962. doi:10.1038/sj.cdd.4401056
Krieser, R. J., MacLea, K. S., Park, J. P., & Eastman, A. (2001). The cloning, genomic structure, localization, and expression of human deoxyribonuclease II beta. GENE, 269(1-2), 205-216. doi:10.1016/S0378-1119(01)00434-6